Over the years, Spyderco has made it crystal clear that if you disassemble your knife, it will void the warranty.
At one point in 2010, Spyderco marketer Kristi Hunter said it in plain terms on the Spyderco forums:
Disassembling a Spyderco voids the warranty. Period. There was a question about this being a “myth”. It is not a myth. It does not matter if you don’t break anything when you do it. If we can tell that a knife has been disassembled (whether it’s a FrankenSpyder or not) the warranty is technically void.
But earlier this month, Spyderco announced that disassembling your knife does not automatically void the warranty.